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RPSC Assistant Professor- Endocrinology Exam Syllabus Details With Paper Pattern

RPSC Assistant Professor Endocrinology recruitment in Medical & Health Education Department is done through an examination which has a definite amount of syllabus and paper pattern. The applicants for the Assistant Professor Endocrinology exam need to make it a point to study all the topics which are the part of syllabus. The questions are asked from the field itself so as to check the knowledge of the applicant for assistant professor post.

Exam pattern- Written Test of 100 questions (1 Mark each) for which the 2 hours’ time duration will be provided.

NOTE: There will be negative marking in the exam.

Exam Syllabus- There are several topics in the exam paper which are covered-

  1. Basic science of endocrinology and metabolism will include the topics-
  • History of Endocrinology, evaluation of concept of endocrine glands, hormones, intermediary metabolism, Influence of human genome project in endocrinology
  • Types of hormones and their molecular structure
  • Regulations of synthesis and secretion of various hormones, Feedback mechanism
  • Biological rhythms
  • Research methodology: Design of study Epidemiology, statistical methods, existing and upcoming laboratory techniques in endocrinology and metabolism.
  • Endocrine disrupters, environmental toxins and endocrinology
  • Dynamic endocrine tests
  • Laboratory Techniques: Hormonal assays of FISH, chromosomal microarray, molecular genetics and biochemical genetics of endocrine and metabolic disorders, RIA, CLIA, IRMA, ELISA, LCMS HPLC, Clinical chemistry of hormone and metabolic disorders, cytogenetics.
  • Basic principles of imaging and their applications in endocrinology: Nuclear imaging including PET scan, CT, MRI, USG and conventional radiology.
  • Mechanism of action of various steroid and peptide hormones
  • Basic principles of Genetics, immunology and oncology as applied to clinical endocrinology and metabolism

  1. Adrenal Glands
  • Adrenal imaging
  • Anatomy and physiology of Adrenal gland
  • Structural, biochemical and molecular pathology of various adrenal disorders
  • Adrenal disorders in special situations like childhood, adolescence and pregnancy
  • Genetic disorders of adrenal gland
  • Drugs used in treatment of adrenal disorders and diagnosis
  • Applications of hormonal assays and other biochemical investigations in diagnosis of various adrenal disorders
  • Dynamic hormonal tests for adrenal dysfunctions
  • Epidemiology, Etiopathogenesis, diagnosis and management of various adrenal disorders like : Cushing syndrome, Addison disease, cogenital adrenal hyperplasia, adrenal tumors, pheochromocytoma, hyperaldosteronism etc. Endocrine hypertension

  1. Metabolic bone disease:
  • Hormonal and metabolic investigations in bone disorders
  • Markers of skeletal metabolism
  • Skeletal ultrastructure and physiology
  • Radiologic assessment of metabolic bone disorders: Conventional X-rays, DEXA, Bone scam
  • Histomorphometry of metabolic bone diseases
  • Regulation of bone mass
  • Bone and mineral metabolic disorders during pregnancy
  • Regulation of calcium, phosphate, magnesium and vitamin D3 metabolism
  • Epidemiology etiopathogensis, diagnosis and management of metabolic bone diseases like- Osteoporosis, Disorders of calcium, Ricketts, osteomalacia, Paget’s disease, osteogenesis imperfecta, osteoporosis, Mc cune Albright syndrome, phosphate and magnesium metabolism
  • Hereditary and congenital disorders of bone and mineral metabolism

  1. Pituitary & Hypothalamus
  • Dynamic tests for pituitary function
  • Embryogenesis, structure, physiology of pituitary and hypothalamus
  • Nuclei of hypothalamus and their relation with pituitary functions
  • Causes of growth hormone deficiency, their genetic transmission, their presentation and treatment
  • Secretion of various releasing hormones of hypothalamus and hormones from pituitary
  • Space occupying lesions in pituitary, their presentation and management
  • Causes of growth hormone excess, their clinical presentation, work up of these patients and various modalities of treatment of patients with growth hormone excess

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  1. Posterior pituitary
  • Mechanism of control of osmolality
  • Development and mechanism of working of posterior pituitary
  • Syndrome of inappropriate antidiuretic hormone (SIADH) its presentation and management
  • Diabetes insipidus definition and various types, work up and management

  1. Growth failure and short stature :
  • Causes of short stature
  • Work up of patient of short stature
  • Growth hormone resistance
  • Presentation of different kind of short stature
  • Hypopituitarism and various types including congenital, Sheehan syndrome, lymphocytic hypophysitis and other varieties,Their presentation and management
  • Treatment of patients of short stature along with growth hormone therapy

  1. Thyroid gland :
  • Nuclear and radiologic imaging.
  • Development, structure, vascular supply of thyroid gland.
  • Synthesis and secretion of thyroid hormones and their regulation.
  • Thyroid function test including hormonal assays, antibodies.
  • Etiopathogensis, presentation work up and management of various thyroid disorders like : Hypothyroidism, hyperthyroidism, thyroiditis, tumors and nodules including thyroid cancer
  • Radio- iodine therapy.
  • Thyroid hormone resistance.
  • Effect of iodination of salt and development of thyroid disorders.
  • Iodine deficiencies and its presentation.
  • Thyroid disorders during infancy, childhood and pregnancy.

  1. Parathyroid gland :
  • Parathyroid imaging.
  • Management of hypercalcemia
  • Development, anatomic structures, eutopic and ectopic parathyroid glands
  • Causes, clinical presentation their evaluation and management of various parathyroid disorders like- Hypoparathyroidsm, Hyperparathyroidism, Parathyroid hormone resistance and parathyroid tumor
  • Surgical management of parathyroid disorders.

  1. Gonads and puberty :
  • Abnormal development of gonads and genitalia, their presentation, evaluation and management of various disorders like : precocious puberty, Female pseudo hermaphrodite, male pseudo hermaphrodite, true hermaphrodite, delayed puberty
  • Somatic stigmata and abnormal pubertal development, work up and management of : Turners syndrome, Klinefelter’s syndrome, kallmann syndrome
  • Clinical presentation work up and management of various disorders like hypogonadotropic hypogonadism, hypergonadotropic hypogonadism
  • Infertility and assisted reproduction

10. Diabetes Mellitus and Metabolic syndrome :

  • Definition, epidemiology, diagnosis and classification of diabetes
  • Newer modalities in diabetes management including CGMS and insulin pumps
  • Etiopathegensis of diabetes including, various genetic mutations for development of type 1, type 2 and MODY (Maturity onset diabetes of young)
  • Clinical presentation work up and management of various types of diabetes : Type 1 Type 2 Gestational diabetes Secondary diabetes MODY (Maturity onset diabetes of young)
  • Newer drugs in management of diabetes like : Insulin analogues, DPP- IV inhibitors, Exenatide , liraglutide
  • Complications of diabetes, their prevalence, presentation, work up and management of (a) Nephropathy (b) Neuropathy(c) Retinopathy (d) Peripheral vascular diseases (e) Hypertension (f) Ischemic heart disease
  • Oral drugs for management of diabetes and their classes and mechanism of action

11. MEN (Multiple endocrine Neoplasia) types, various glands affected, their genetic transmission, presentation, treatment and management of carrier stage. Molecular diagnostics as applied to MEN

12. Auto immune endocrinopathies Types, etiopathogenesis presentation, genetic transmission and management of various auto-immune endocrine disorders including polyglandular auto-immune syndromes.

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